ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue

Oct 01, 2020

The SFB researchers Valérie Hilgers (B4), Dominika Grzejda (B4), Carlos-Alfonso Gonzalez (B4) and others could show that the two neuron-specific RNA-binding proteins ELAV and FNE define the unique identity of neuronal messenger RNAs. When not repressed by ELAV, FNE undergoes a functional switch and rescues neuronal RNA processing in a process termed exon- activated functional rescue. Publication in Molecular Cell.

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