The Goal of the SFB 1381
The SFB 1381 investigates how different proteins are dynamically assembled into complex multimers, the so-called protein machineries, which play a central role e.g. in the energy metabolism of the cell, the replication, repair, and transcription of DNA, the folding and degradation of proteins, as well as the intra- and intercellular communication and transport processes. The focus of the SFB 1381 lies on the organization of these protein machineries in modular units, the regulation of their assembly and disassembly, and the impact of these processes on cellular functions.
The aim of the SFB 1381 is to define and understand the dynamic processes of the assembly and organization of cellular protein machineries, and to gain insight into the fundamental processes in a living cell.
Impressions of the 2nd International Symposium of the SFB 1381
Video Jürgen Gocke
Imagefilm of SFB 1381
Video Jürgen Gocke (also available on Youtube)
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Selected Publications
Taskin, A.A., Shankar, S., Peselj, C., Flotho, A., Gomez-Fabra Gala, M., Poveda-Huertes, D., Myketin, L., Mutlu, D., Marada, A., Schuck, S., Jeske, M., Buttner, S., Luzarowski, M., Meisinger, C. and Vögtle, F.N. (2026) Uncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt. Mol. Cell 86, 2157-2172 e2110
Shen, K., Ozturk, Y., Jimenez-Niebla, J., Emmanuel, P.D., Ruoff, K., Cosenza-Contreras, M., Drepper, F., Huesgen, P., Hunte, C., Daldal, F. and Koch, H.G. (2026) Distinct Assembly Complexes facilitate cbb(3)-type Cytochrome Oxidase Maturation. J. Mol. Biol. 169945, online ahead of print
Wallner, T., He, C., Samir, S., Lopes, E.S., Zeng, X., Zhang, C.C., Selim, K.A., Yang, Y. and Wilde, A. (2026) Regulation of cyanobacterial type IV pilus-dependent functions by interaction between a c-di-GMP receptor and two transcription factors. Microbiol. Res. 311, 128607
Joest, M., Mollat, C.L., Mutschler, L., Rodriguez-Franco, M., Sivabalasarma, S., Drepper, F., Huesgen, P.F., Ott, T. and Albers, S.V. (2026) A multilayered cell envelope of a member of the Chloroflexota offers an anchoring platform for the archaellum. Front. Microbiol. 17, 1850455
Babic, R., Lucya, L., Reiter, C., Kriegenburg, F., Castellanos-Martinez, R., Hollenstein, D.M., Becker, F., Hunte, C. and Kraft, C. (2026) A ULK1-MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis. J. Cell Sci. 139
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Administration
Gabriele Reindl
Institute of Biochemistry and Molecular Biology
University of Freiburg
