The SFB 1381 investigates how different proteins are dynamically assembled into complex multimers, the so-called protein machineries, which play a central role e.g. in the energy metabolism of the cell, the replication, repair, and transcription of DNA, the folding and degradation of proteins, as well as the intra- and intercellular communication and transport processes. The focus of the SFB 1381 lies on the organization of these protein machineries in modular units, the regulation of their assembly and disassembly, and the impact of these processes on cellular functions.
The aim of the SFB 1381 is to define and understand the dynamic processes of the assembly and organization of cellular protein machineries, and to gain insight into the fundamental processes in a living cell.
On the 8th and 9th of March 2021 all SFB researchers met virtually for the annual retreat. Although we could not meet in person, the meeting was a great success.
Thanks to all participants for their excellent contributions!
Dr. Laura Gámez-Días from the Institute of Immunodeficency, University Medical Center Freiburg, and Dr. Sascha Yousefi from the Institute of Biology, University of Freiburg are the Young Investigator Grantees of the SFB 1381.
Asifa Akhtar (Project B3) received the Gottfried Wilhelm Leibniz Prize 2021 by the German Research Foundation (DFG) for her outstanding work on the regulation of the genome.
The SFB researchers Valérie Hilgers (B4), Dominika Grzejda (B4), Carlos-Alfonso Gonzalez (B4) and others could show that the two neuron-specific RNA-binding proteins ELAV and FNE define the unique identity of neuronal messenger RNAs. When not repressed by ELAV, FNE undergoes a functional switch and rescues neuronal RNA processing in a process termed exon- activated functional rescue. Publication in Molecular Cell.
SFB 1381 is partner organizer of the first international CIBSS Symposium “Signalling across Scales”, November 23-25, 2020.
On the 12th and 13th of March 2020 the PIs of the SFB 1381 had their first retreat in the black forest at Hotel Saigerhöh. It was a very successful meeting and we are very much looking forward to the follow-up meeting next year!
SFB researchers Nora Vögtle (Project B4), Daniel Poveda-Huertes (Project A6), Chris Meisinger (Project A6) and Claudine Kraft (Project B10) discovered link of the mitochondrial presequence processing machinery to a nuclear stress response. Publication in Molecular Cell.