The SFB 1381 investigates how different proteins are dynamically assembled into complex multimers, the so-called protein machineries, which play a central role e.g. in the energy metabolism of the cell, the replication, repair, and transcription of DNA, the folding and degradation of proteins, as well as the intra- and intercellular communication and transport processes. The focus of the SFB 1381 lies on the organization of these protein machineries in modular units, the regulation of their assembly and disassembly, and the impact of these processes on cellular functions.
The aim of the SFB 1381 is to define and understand the dynamic processes of the assembly and organization of cellular protein machineries, and to gain insight into the fundamental processes in a living cell.
On the 12th and 13th of March 2020 the PIs of the SFB 1381 had their first retreat in the black forest at Hotel Saigerhöh. First results and achievements of the projects were presented and intensively discussed. Thereby, the manyfold interactions and collaborations among the different projects became clearly visible. It was a very successful meeting and we are very much looking forward to the follow-up meeting next year!
SFB researchers Nora Vögtle (Project B4), Daniel Poveda-Huertes (Project A6), Chris Meisinger (Project A6) and Claudine Kraft (Project B10) discovered link of the mitochondrial presequence processing machinery to a nuclear stress response. Publication in Molecular Cell.
Sonja Albers (Project A1), Shamphavi Sivabalasarma (Project A1) and others could identify proteins that are essential for the motility structure of archaea. These findings were published in Nature Microbiology.
Maja Banks-Köhn (Project A6) recieved a Consolidator Grant of two million euros from the ERC for a period of five years.
A versatile cryoslicing BN-MS protocol using a microtome for high-resolution complexome profiling was established by the SFB researchers Catrin Müller (Project A8), Wolfgang Bildl (Project Z1), Bernd Fakler (Project A8) and Uwe Schulte (Project Z1).