The Goal of the SFB 1381
The SFB 1381 investigates how different proteins are dynamically assembled into complex multimers, the so-called protein machineries, which play a central role e.g. in the energy metabolism of the cell, the replication, repair, and transcription of DNA, the folding and degradation of proteins, as well as the intra- and intercellular communication and transport processes. The focus of the SFB 1381 lies on the organization of these protein machineries in modular units, the regulation of their assembly and disassembly, and the impact of these processes on cellular functions.
The aim of the SFB 1381 is to define and understand the dynamic processes of the assembly and organization of cellular protein machineries, and to gain insight into the fundamental processes in a living cell.
Impressions of the 2nd International Symposium of the SFB 1381
Video Jürgen Gocke
Imagefilm of SFB 1381
Video Jürgen Gocke (also available on Youtube)
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Selected Publications
Babic, R., Lucya, L., Reiter, C., Kriegenburg, F., Castellanos-Martinez, R., Hollenstein, D.M., Becker, F., Hunte, C. and Kraft, C. (2026) A ULK1-MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis. J. Cell Sci., online ahead of print
Heinen, S., Tiku, V., Grevel, A., Hugenroth, M., Ellenrieder, L., Steymans, I., Licheva, M., Bonini, S., Oeljeklaus, S., Okon, N., Lambertz, J., Poppe, S., Song, J., Fester, L., Meisinger, C., Warscheid, B., Eckhardt, M., Wiedemann, N., Winter, D., Kraft, C., den Brave, F., Bohnert, M., Pfanner, N. and Becker, T. (2026) Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1. Nat. Cell Biol. 28, 436-448
Zhang, Y., Grundmann, L., Vollmar, L., Schimpf, J., Hubscher, V., Areeb, M., Grishkovskaya, I., Moddemann, A., Werner, K., Hugel, T., Haselbach, D. and Rospert, S. (2026) The cotranslational cycle of the ribosome-bound Hsp70 homolog Ssb. Nat. Commun. 17, 961
Scheinost, L., Ludwig, C., Höfflin, N., Taskin, A.A., Marada, A., Vögtle, F.N., Meisinger, C. and Köhn, M. (2026) Synthetic trap-peptides identify a TOM complex phosphatase – PP2A dephosphorylates Tom6. FEBS J. 293, 271-294
Samir, S., Doello, S., Enkerlin, A.M., Zimmer, E., Haffner, M., Muller, T., Dengler, L., Lambidis, S.P., Sivabalasarma, S., Albers, S.V. and Selim, K.A. (2025) The second messenger c-di-AMP controls natural competence via ComFB signaling protein. Cell Discov. 11, 65
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Administration
Gabriele Reindl
Institute of Biochemistry and Molecular Biology
University of Freiburg
