The SFB 1381 investigates how different proteins are dynamically assembled into complex multimers, the so-called protein machineries, which play a central role e.g. in the energy metabolism of the cell, the replication, repair, and transcription of DNA, the folding and degradation of proteins, as well as the intra- and intercellular communication and transport processes. The focus of the SFB 1381 lies on the organization of these protein machineries in modular units, the regulation of their assembly and disassembly, and the impact of these processes on cellular functions.
The aim of the SFB 1381 is to define and understand the dynamic processes of the assembly and organization of cellular protein machineries, and to gain insight into the fundamental processes in a living cell.
The SFB researchers Valérie Hilgers (B4), Dominika Grzejda (B4), Carlos-Alfonso Gonzalez (B4) and others could show that the two neuron-specific RNA-binding proteins ELAV and FNE define the unique identity of neuronal messenger RNAs. When not repressed by ELAV, FNE undergoes a functional switch and rescues neuronal RNA processing in a process termed exon- activated functional rescue. Publication in Molecular Cell.
CALL FOR TWO YOUNG INVESTIGATOR GRANTS AT THE SFB 1381 (2 x 30.000 Euro)
“Dynamic Organization of Cellular Protein Machineries: From Biogenesis and Modular Assembly to Function”
The SFB 1381 seeks for two highly talented and successful post-docs that are in the transition phase from post-doc to group leader (max. 5 years after PhD).
SFB 1381 is partner organizer of the first international CIBSS Symposium “Signalling across Scales”, November 23-25, 2020.
On the 12th and 13th of March 2020 the PIs of the SFB 1381 had their first retreat in the black forest at Hotel Saigerhöh. First results and achievements of the projects were presented and intensively discussed. Thereby, the manyfold interactions and collaborations among the different projects became clearly visible. It was a very successful meeting and we are very much looking forward to the follow-up meeting next year!
SFB researchers Nora Vögtle (Project B4), Daniel Poveda-Huertes (Project A6), Chris Meisinger (Project A6) and Claudine Kraft (Project B10) discovered link of the mitochondrial presequence processing machinery to a nuclear stress response. Publication in Molecular Cell.
Sonja Albers (Project A1), Shamphavi Sivabalasarma (Project A1) and others could identify proteins that are essential for the motility structure of archaea. These findings were published in Nature Microbiology.
Maja Banks-Köhn (Project A6) recieved a Consolidator Grant of two million euros from the ERC for a period of five years.
SFB researchers Bernd Fakler (Project A8), Uwe Schulte (Project Z1) and Wolfgang Bildl (Project Z1) could provide a mechanistic insight into the stepwise biogenesis of AMPARs in native ER membranes and established FRRS1l as a powerful regulator of synaptic signaling and plasticity.
Publication in Neuron.
A versatile cryoslicing BN-MS protocol using a microtome for high-resolution complexome profiling was established by the SFB researchers Catrin Müller (Project A8), Wolfgang Bildl (Project Z1), Bernd Fakler (Project A8) and Uwe Schulte (Project Z1).