Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Sep 01, 2020
Wolfgang Schamel (Project A9) and Susana Minguet discovered that the kinase Lck is dynamically assembled into the T cell receptor signalosome. The investigators applied this knowledge to improve T cell-based cancer immunotherapy in pre-clinical settings.
Publication in Nature Immunology.