Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Wolfgang Schamel (Project A9) and Susana Minguet discovered that the kinase Lck is dynamically assembled into the T cell receptor signalosome. The investigators applied this knowledge to improve T cell-based cancer immunotherapy in pre-clinical settings.

Publication in Nature Immunology.

Image: https://doi.org/10.1038/d41586-019-03083-5