Dynamic Assembly, Localization and Rotation of the Archaellum

Project Summary

The archaellum is the motility machinery that archaea use to move in liquid media. It is evolutionary linked to bacterial type IV pili, but generates movement by a rotating filament which is driven by ATP hydrolysis. Using biochemical and structural methods, we aim to understand the modular assembly of the archaellum subunits and how their interplay enables torque generation. We will employ the model H. volcanii to gain spatio-temporal information of the assembly process in vivo.