Dynamic Assembly and Rotation of the Archaellum Motor Complex

Project Summary

The archaellum is the motility structure used by archaea to move in liquid media. It is evolutionary linked to type IV pili in archaea and bacteria, but generates movement by a rotating filament which is driven by ATP hydrolysis. As so far only limited information is available on how the archaellar filament is assembled into functional modules to allow rotation, we will employ biochemical, structural and physiological methods to understand and elucidate these processes.