Identification and Characterization of MOF Interaction and Substrate Repertoire

Project Summary

Histone acetylation is a prominent epigenetic modification playing diverse roles in several cel-ular processes. MOF (Males absent On the First) is the major lysine acetyl transferase responsible for deposition of histone H4 lysine 16 (H4K16ac). We found that MOF dually localizes to the nucleus and mitochondria. We will study the function of mitochondrial MOF sub-complexes and investigate the consequences of MOF acetylation of mitochondrial proteins on mitochondrial functions.