Assembly, Dynamics and Function of ELAV Protein Machineries in Neurons

Project Summary

In Drosophila, the protein ELAV causes an extension of the 3’ UTR of hundreds of genes, exclusively in neurons. We will dissect the assembly and modular composition of the nuclear and cytoplasmic ELAV-containing ribonucleoprotein subcomplexes. We will focus on the formation of condensates by nuclear ELAV-subassemblies and also analyse the cellular consequences caused by targeted disruption of distinct subcomplexes to elucidate their physiological functions..