mTOR and Ribonucleoprotein Complex Dynamics under Stress

Project Summary

mTORC1 and 2 complexes respond to nutrient availability and external stimuli by dynamic re-composition and changes in their localization to determine crucial functions in metabolism, intracellular dynamics and stress control. Our proposed work in C. elegans and human cells aims at investigating the dynamic assembly/disassembly and the activity of the mTOR complexes in response to stress, analysing the role of stress-dependent ribonucleoprotein shuttling involving mTORC components and their regulators.