Assembly and biogenesis of respiratory complex III and of related supercomplexes

Project Summary

Cellular respiration is essential for life. It is accomplished by a sophisticated machinery of membrane-bound, multiprotein and cofactor-bearing respiratory complexes that can form higher-order structures called supercomplexes. The assembly of these complexes must take place in a tightly regulated and dynamic manner in order to avoid partially assembled malfunctioning complexes and to meet changing energetic demands of the cell. We will provide in-depth structural and mechanistic insight into the coordinated assembly and biogenesis of respiratory complex III – a key component of the mitochondrial respiratory chain – and of related supercomplexes.